Institut für Systembiotechnologie


  • Seo K, Shu W, Rückert-Reed C, Gerlinger P, Erb T, Kalinowski J, Wittmann C (2023)

    From waste to health-supporting molecules: biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans.

    Microb. Cell Fact. 22:262. PUBMED.

  • Stegmüller J, Rodríguez Estévez M, Shu W, Gläser L, Myronovskyi M, Rückert-Reed C, Kalinowski J, Luzhetskyy A, Wittmann C (2023)

    Systems Metabolic Engineering of Streptomyces albidoflavus at the level of primary and secondary metabolism enhances production of the reverse anitbiotic nybomycin against multi-resistant Staphylococcus aureus.

    Metab. Eng. 81:123-143. PUBMED.

  • Pause L, Weimer A, Wirth NT, Nguyen AV, Lenz C, Kohlstedt M, Wittmann C, Nikel PI, Lai B, Krömer JO (2023)

    Anaerobic glucose uptake in Pseudomonas putida KT2440 in a bioelectrochemical system.

    Microb. Biotechnol. In press. PUBMED.

  • Beganovic S, Rückert-Reed C, Sucipto H, Shu W, Gläser L, Patschkowski T, Struck B, Kalinowski J, Luzhetskyy A, Wittmann C (2023)

    Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer.

    Microb. Cell Fact. 22:222. PUBMED.

  • Dietrich DL, Jovanovic S, Cao P, Kohlstedt M, Wittmann C (2023)

    Refactoring the genetic architecture of a myxobacterial polyketide gene cluster enables enhanced heterologous docosahexaenoic acid production in Yarrowia lipolytica.

    Microb. Cell Fact. 22:199. PUBMED.

  • Jovanovic S, Dietrich DL, Cao P, Kohlstedt M, Wittmann C (2023)

    Multi-omics view of recombinant Yarrowia lipolytica: Enhanced ketogenic amino acid catabolism increases polyketide-synthase-driven docosahexaenoic production to high selectivity at the gram scale.

    Metab. Eng. 80:45-65. PUBMED.

  • Tangyu M, Fritz M, Tan JP, Ye L, Bolten CJ, Bogicevic B, Wittmann C (2023)

    Flavour by design: Food-grade lactic acid bacteria improve the volatile aroma spectrum of oat milk, sunflower seed milk, pea milk, and faba milk towards improved flavour and sensory perception.

    Microb. Cell Fact. 22:133. PUBMED.

  • Pauli S, Lamber J, Kohlstedt M, Becker J, Wittmann C (2023)

    Systems metabolic engineering upgrades Corynebacterium glutamicum to high-level production of the chiral drug precursor and cell-protective extremolyte L-pipecolic acid.

    Metab. Eng. 77:100-117. PUBMED.

  • Christmann J, Cao P, Desiderato CK, Goldbeck O, Kohlstedt M, Becker J, Riedel CU, Wittmann C (2023)

    High-efficiency production of the antimicrobial peptide pediocin PA-1 in metabolically engineered C. glutamicum using a microaerobic process at acidic pH and elevated levels of bivalent calcium ions

    Microb. Cell Fact. 22:41. PUBMED.

  • Weiland F, Barton N, Kohlstedt M, Becker J, Wittmann C (2023)

    Systems metabolic engineering upgrades Corynebacterium glutamicum to high-efficiency cis, cis-muconic acid production from lignin-based aromatics.

    Metab. Eng. 75:153-169. PUBMED.