Institut für Systembiotechnologie


  • Korneli C, Biedendieck R, David F, Jahn D, Wittmann C (2013)

    High yield production of extracellular recombinant levansucrase by Bacillus megaterium.

    Appl. Microbiol. Biotechnol. 97:3343-3353.

  • Kind S, Becker J, Wittmann C (2013)

    Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway - metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum.

    Metab. Eng. 15:184-195.

  • Krull R, Wucherpfennig T, Eslahpazir Esfandabadi M, Walisko R, Melzer G, Hempel D C, Kampen I, Kwade A, Wittmann C (2013)

    Characterization and control of fungal morphology for improved production performance in biotechnology.

    J. Biotechnol. 163:112-123.

  • Schiefelbein S, Froehlich A, John GT, Beutler F, Wittmann C, Becker J (2013)

    Oxygen supply in disposable shake flasks - prediction of oxygen transfer rate, oxygen saturation and maximum cell concentration during aerobic growth.

    Biotechnol. Lett. 35:1223-1230.

  • Buschke N, Becker J, Schäfer R, Kiefer P, Biedendieck R, Wittmann C (2013)

    Systems metabolic engineering of xylose utilizing Corynebacterium glutamicum for production of 1,5-diaminopentane.

    Biotechnol. J. 8:557-70.

  • Bergmann S, David F, Franco-Lara E, Wittmann C, Krull R (2013)

    Ectoine production by Alkalibacillus haloalkaliphilus – bioprocess development using response surface methodology and model-driven strategies.

    Eng. Life Sci. 13:399-407.

  • Buschke, N, Schäfer R, Becker J, Wittmann C (2013)

    Metabolic engineering of industrial platform microorganisms for biorefinery applications - optimization of substrate spectrum and process robustness by rational and evolutive strategies.

    Biores. Technol. 135:544-554.

  • Poblete-Castro I, Binger D, Rodrigues A L, Becker J, Dos Santos V, Wittmann C (2013)

    In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates.

    Metab. Eng. 15:113-123.

  • Becker J, Reinefeld J, Stellmacher R, Schäfer R, Lange A, Meyer H, Lalk M, Zelder O, von Abendroth G (2013)

    Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinic acid producing Basfia succiniciproducens.

    Biotechnol. Bioeng. 110:3013-3023.

  • Korneli C, David F, Biedendieck R, Jahn D, Wittmann C (2013)

    Getting the big beast to work - systems biotechnology of Bacillus megaterium for novel high-value proteins.

    J. Biotechnol. 163:87-96.

  • Ebert M, Laaß S, Burghartz M, Petersen J, Koßmehl S,Wöhlbrand L, Rabus R, Wittmann C, Tielen P, Jahn (2013)

    Transposon mutagenesis identified chromosomal and plasmid encoded genes essential for the adaptation of the marine bacterium Dinoroseobacter shibae to anaerobic conditions.

    J. Bacteriol. 195:4769-4777.

  • Kim JY, Wittmann C, Park JB (2013)

    Production of non-proteinogenic amino acids from α-keto acid precursors with recombinant Corynebacterium glutamicum.

    Biotechnol. Bioeng. 110:2846-2855.

  • Adler P, Bolten CJ, Dohnt K, Hansen CE, Wittmann C (2013)

    Core fluxome and meta fluxome of lactic acid bacteria under cocoa pulp fermentation simulating conditions.

    Appl. Environ. Microb. 79: 5670-5681.

  • Bergmann S, David F, Clark W, Wittmann C, Krull R (2013)

    Membrane fluidity of halophilic ectoine secreting bacteria related to osmotic and thermal treatment.

    Bioproc. Biosyst. Eng. 36: 1829-1841.

  • Becker J, Schäfer R, Kohlstedt M, Harder BJ, Borchert NS, Stöveken N, Bremer E, Wittmann C (2013)

    Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine.

    Microb. Cell. Fact. 12:110.

  • van Duuren JB, Puchałka J, Mars AE, Bücker R, Eggink G, Wittmann C, Dos Santos VA (2013)

    Reconciling in vivo and in silico key biological parameters of Pseudomonas putida KT2440 during growth on glucose under carbon-limited condition.

    BMC Biotechnol. 13:93.

  • Rodrigues AL, Trachtmann N, Becker J, Blotenberg J, Lohanatha A, Bolten C, Korneli C, de Souza Lima A (2013)

    Systems metabolic engineering of Escherichia coli for production of the antitumor drugs violacein and deoxyviolacein.

    Metab. Eng. 20:29-41