Institut für Systembiotechnologie


  • Schwechheimer, SK, Becker, J, Peyriga, L, Portais JC, Wittmann, C (2018)

    Metabolic flux analysis in Ashbya gossypii using 13C-labeled yeast extract: industrial riboflavin production under complex nutrient conditions.

    Microb. Cell Fact. 17:162. PUBMED.

  • Rohles, CM, Gläser, L, Kohlstedt, M, Gießelmann, G, Pearson, S, del Campo, A, Becker, J, Wittmann, C (2018)

    Bio-based route to the carbon-5 chemical glutaric acid and to bionylon-6,5 using metabolically engineered Corynebacterium glutamicum.

    Green Chem. 20:4662-4674. PUBMED.

  • Schwechheimer, SK, Becker, J, Wittmann, C (2018)

    Towards better understanding of industrial cell factories: novel approaches for 13C metabolic flux analysis in complex nutrient environments.

    Curr. Opin. Biotechnol. 54:128-137. PUBMED.

  • Becker, J, Rohles, CM, Wittmann, C (2018)

    Metabolically engineered Corynebacterium glutamicum for bio-based production of chemicals, fuels, materials, and healthcare products.

    Metab. Eng. 50:122-141. PUBMED.

  • Becker, J, Kuhl, M, Kohlstedt, M, Starck, S, Wittmann, C (2018)

    Metabolic engineering of Corynebacterium glutamicum for the production of cis,cis-muconic acid from lignin.

    Microb. Cell Fact. 17:115. PUBMED.

  • Becker, J, Wittmann, C (2018)

    From systems biology to metabolically engineered cells – an omics perspective on the development of industrial microbes

    Curr. Opin. Microbiol. 45:180-188. PUBMED.

  • Hoffmann, SL, Jungmann, L, Schiefelbein, S, Peyriga, L, Cahoreau, E, Portais, JC, Becker, J, Wittmann, C (2018)

    Lysine production from the sugar alcohol mannitol: Design of the cell factory Corynebacterium glutamicum SEA-3 through integrated analysis and engineering of metabolic pathway fluxes

    Metab. Eng. 47:475-487 PUBMED.

  • Schwechheimer, SK, Becker, J, Peyriga, L, Portais, JC, Sauer, D, Müller, R, Hoff, B, Haefner, S, Schröder, H, Zelder, O, Wittmann, C (2018)

    Improved riboflavin production with Ashbya gossypii from vegetable oil based on 13C metabolic network analysis with combined labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR

    Metab. Eng. 47:357-373. PUBMED.

  • Kohlstedt, M, Starck, S, Barton, N, Stolzenberger, J, Selzer, M, Mehlmann, K, Schneider, R, Pleissner, D, Rinkel, J, Dickschat, JS, Venus, J, van Duuren, J, Wittmann, C (2018)

    From lignin to nylon: Cascaded chemical and biochemical conversion using metabolically engineered Pseudomonas putida

    Metab. Eng. 47:279-293. PUBMED.

  • Barton, N, Horbal, L, Starck, S, Kohlstedt, M, Luzhetskyy, A, Wittmann, C (2018)

    Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp. ATCC 39116

    Metab. Eng. 45:200-210. PUBMED.

  • Vassilev I, Gießelmann G, Schwechheimer SK, Wittmann C, Virdis B, Krömer JO (2018)

    Anodic Electro-Fermentation: Anaerobic production of L-Lysine by recombinant Corynebacterium glutamicum.

    Biotechnol. Bioeng. 115:1499-1508. PUBMED.