Institut für Systembiotechnologie


  • Kiefer P, Heinzle E, Zelder O, Wittmann C (2004)

    Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose.

    Appl. Env. Microbiol. 70:229-39

  • Krömer JO, Sorgenfrei O, Klopprogge K, Heinzle E, Wittmann C (2004)

    In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of transcriptome, metabolome, and fluxome.

    J. Bacteriol. 186:1769-1784

  • Kumar S, Wittmann C, Heinzle E (2004)


    Biotechnol. Lett. 26:1-10

  • Wittmann C, Hans M, van Winden W, Ras C, Heijnen J (2004)

    Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle related oscillation in Saccharomyces cerevisiae.

    Biotechnol. Bioeng. 89:839-47

  • Wittmann, C, Kiefer P, Zelder O (2004)

    Metabolic fluxes in Corynebacterium glutamicum during lysine production on sucrose.

    Appl. Env. Microbiol. 70:7277-7287

  • Wittmann C, Schütz V, John G, Heinzle E (2004)

    Quantification of oxygen transfer in test tubes by integrated optical sensing.

    J. Microbiol. Biotechnol. 14:991-995

  • Yang TH., Wittmann C, Heinzle E (2004)

    Membrane inlet mass spectrometry for the on-line measurement of metabolic fluxes in the case of lysine-production by Corynebacterium glutamicum.

    Life Sci. 4:252-257

  • Wittmann C, Kim HM, Heinzle E (2004)

    Metabolic flux analysis of lysine producing Corynebacterium glutamicum at miniaturized scale.

    Biotechnol. Bioeng. 87:1-6

  • Wittmann C, Kähkönen M A, Ilvesniemi H, Kurola J, Salkinoja-Salonen M S (2004)

    Areal activities and stratification of hydrolytic enzymes involved in the biochemical cycles of carbon, nitrogen, sulphur and phosphorus in podsolized boreal forest soils.

    Soil Biol. Biochem. 36:425-433

  • Yang TH, Wittmann C, Heinzle E (2004)

    Metabolic network simulation using logical loop algorithm and jacobian matrix.

    Metab. Eng. 6:256-267