Institut für Systembiotechnologie


  • Weiland F, Kohlstedt M, Wittmann C (2021)

    Guiding stars to the field of dreams: Metabolically engineered pathways and microbial platforms for a sustainable lignin-based industry.

    Metab. Eng. 71:13-41. PUBMED.

  • Goldbeck O, Desef DN, Ovchinnikov KV, Perez-Garcia F, Christmann J, Sinner P, Crauwels P, Weixler D, Cao P, Kohlstedt M, Becker J, Kager J, Eikmanns BJ, Seibold GM, Herwig C, Wittmann C, Bar NS, Diep DB, Riedel CU (2021)

    Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum.

    Metab. Eng. 68:34-45. PUBMED.

  • Hoffmann SL, Kohlstedt M, Jungmann L, Hutter M, Poblete-Castro I, Becker J, Wittmann C (2021)

    Cascaded valorization of brown seaweed to produce L-lysine and value-added products using Corynebacterium glutamicum streamlined by systems metabolic engineering.

    Metab. Eng. 67:293-307. PUBMED.

  • Millard P, Sokol S, Kohlstedt M, Wittmann C, Letisse F, Lippens G, Portais JC (2021)

    IsoSolve: an integrative framework to improve isotopic coverage and consolidate isotopic measurements by MS and/or NMR.

    Anal. Chem. 93:9428–9436. PREPRINT. PUBMED.

  • Gläser L, Kuhl M, Stegmüller J, Rückert C, Myronovskyi M, Kalinowski J, Luzhetskyy A, Wittmann C (2021)

    Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2.

    Microb. Cell Fact. 20:111. PUBMED.

  • Kuhl M, Rückert C, Gläser L, Beganovic S, Luzhetskyy A, Kalinowski J, Wittmann C (2021)

    Microparticles enhance the formation of seven major classes of natural products in native and metabolically engineered actinobacteria through accelerated morphological development.

    Biotechnol. Bioeng. 118:3076-3093. PUBMED.

  • Tangyu M, Fritz M, Aragao-Börner R, Ye L, Bogicevic B, Bolten CJ, Wittmann C (2021)

    Genome-based selection and application of food-grade microbes for chickpea milk fermentation towards increased L-lysine content, elimination of indigestible sugars, and improved flavour.

    Microb. Cell Fact. 20:109. PUBMED.

  • Wolf S, Becker J, Tsuge Y, Kawaguchi H, Kondo A, Marienhagen J, Bott M, Wendisch VF, Wittmann C (2021)

    Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being.

    Essays Biochem. EBC20200134. PUBMED.

  • Gummerlich N, Manderscheid N, Rebets Y, Myronovskyi M, Gläser L, Kuhl M, Wittmann C, Luzhetskyy A (2021)

    Engineering the precursor pool to modulate the production of pamamycins in the heterologous host S. albus J1074.

    Met. Eng. 67:11-18. PUBMED.

  • Jovanovic S, Dietrich DL, Kohlstedt M, Becker J, Wittmann C (2021)

    Microbial production of polyunsaturated fatty acids – high-value ingredients for aquafeed, superfoods, and pharmaceuticals.

    Curr. Opin. Biotechnol. 69:199-211. PUBMED.

  • Borrero-de Acuña JM, Gutierrez-Urrutia I, Hidalgo-Dumont C, Aravena-Carrasco C, Orellana-Saez M, Palominos-Gonzalez N, van Duuren JBJH, Wagner V, Gläser L, Becker J, Kohlstedt M, Zacconi FC, Wittmann C, Poblete-Castro I (2021)

    Channeling carbon flux through the meta-cleavage route for improved poly(3-hydroxyalkanoate) production from benzoate and lignin-based aromatics in Pseudomonas putida H

    Microb. Biotechnol. 14:2385-2402. PUBMED.