Institut für Systembiotechnologie


  • Jungmann L, Hoffmann SL, Lang C, De Agazio R, Becker J, Kohlstedt M, Wittmann C (2022)

    High-efficiency production of 5-hydroxyectoine using metabolically engineered Corynebacterium glutamicum.

    Microb. Cell Fact. 21:274. PUBMED.

  • Dolan S, Wijaya A, Kohlstedt M, Gläser L, Brear P, Silva-Rocha R, Wittmann C, Welch M (2022)

    Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism.

    mBio. In press. PUBMEDPreprint.

  • Rohles C*, Pauli S*, Giesselmann G, Kohlstedt M, Becker J, Wittmann C (2022)

    Systems metabolic engineering of Corynebacterium glutamicum eliminates all by-products for selective and high-yield production of the platform chemical 5-aminovalerate.

    Metab. Eng. 73:168-181. PUBMED.
    * both authors contributed equally

  • Kohlstedt M, Weimer A, Weiland F, Stolzenberger J, Selzer M, Sanz M, Kramps L, Wittmann C (2022)

    Biobased PET from lignin using an engineered cis,cis-muconate-producing Pseudomonas putida strain with superior robustness, energy and redox properties.

    Metab. Eng. 72:337-352. PUBMED.

  • Dahlem C, Chanda S, Hemmer J, Kohlstedt M, Wittmann C, Kiemer AK (2022)

    Characterization of anti-cancer activities of violacein: Actions on tumor cells and the tumor microenvironment.

    Front. Oncol. 12:872223. PUBMED.

  • Schulze D, Kohlstedt M, Becker J, Cahoreau E, Peyriga L, Makowka A, Hildebrand S, Gutekunst K, Portais JC, Wittmann C (2022)

    GC/MS-based 13C metabolic flux analysis resolves the parallel and cyclic photomixotrophic metabolism of Synechocystis sp. PCC 6803 and selected deletion mutants including the Entner-Doudoroff and phosphoketolase pathways.

    Microb. Cell Fact. 21:69. PUBMED.

  • Tangyu M, Fritz M, Ye L, Börner RA, Morin-Rivron, Campos-Giménez E, Bolten CJ, Bogicevic B, Wittmann C (2022)

    Co-cultures of Propionibacterium freudenreichii and Bacillus amyloliquefaciens cooperatively upgrade sunflower seed milk to high levels of vitamin B12 and multiple co-benefits.

    Microb. Cell Fact. 21:48. PUBMED.

  • Weixler D, Berghoff M, Ovchinnikov KV, Reich; SJ, Goldbeck O, Seibold GM, Wittmann C, Bar NS, Eikmanns BJ, Diep DB, Riedel CU (2022)

    Recombinant production of the lantibiotic nisin using Corynebacterium glutamicum in a two-step process.

    Microb. Cell Fact. 21:11. PUBMED.