Institut für Systembiotechnologie


  • Wittmann, C (2007)

    Fluxome analysis using GC-MS.

    Microb. Cell Fact. 6:6.

  • Wittmann C, Weber J, Betiku E, Krömer J O, Böhm D, Rinas U (2007)

    Response of fluxome and metabolome to temperature-induced recombinant protein synthesis in Escherichia coli.

    J. Biotechnol. 132:375-384.

  • Velagapudi V, Wittmann C, Schneider E, Heinzle E (2007)

    Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function.

    J. Biotechnol. 132:395-404.

  • Van der Werft M, Takors R, Smedsgard J, Nielsen J, Ferenci T, Portais J C, Wittmann C, Hooks M, Tomassini A, Oldiges M, Fostel J, Sauer U (2007)

    Standard reporting requirements for biological samples in metabolomics experiments: microbial and in vitro biology experiments.

    Metabolomics 3:189-194.

  • Schneiker S, Perlova O, Alici A, Altmeyer M O, Bartels D, Bekel T, Beyer S, Blöcker H, Bode E, Bode H B, Bolten C J, Choudhuri J V, Doss S, Elnakady Y A, Frank B, Gaigalat L, Gerth K, Goesmann A, Groeger C, Gross F, Jelsbak L, Kaiser O, Kalinowski J, Kegler K, Knauber T, Konietzny S, Kopp M, Krause L, Krug D, Linke B, Mahmud T, Martinez-Arias R, McHardy A C, Merai M, Meyer F, Mormann S, Muñoz-Dorado J, Perez J, Rachid S, Raddatz G, Rosenau F, Rückert C, Sasse F, Scharfe M, Schuster C, Suen G, Treuner-Lange A, Velicer G J, Vorhölter F J, Weissman K J, Welch R D, Wenzel S C, Whitworth D, Wilhelm S, Wittmann C, Pühler A, Müller R (2007)

    Complete sequence of the largest known bacterial genome from the myxobacterium Sorangium cellulosum.

    Nat. Biotechnol. 25:1281-1289.

  • Schilling O, Frick O, Herzberg C, Ehrenreich A, Heinzle E, Wittmann C, Stülke J (2007)

    Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: Transcription regulation is important but not sufficient to account for metabolic adaptation.

    Appl. Environ. Microbiol. 73:499-507.

  • Nicolas C, Kiefer P, Letisse F, Krömer J, Massou S, Soucaille P, Wittmann C, Lindley N D, Portais J C (2007)

    Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase.

    FEBS Lett. 581:3771-3776.

  • Hollemeyer K, Velagapudi V, Wittmann C, Heinzle E (2007)

    Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol.

    Rapid Commun. Mass Spectrom. 21:336-342.

  • Fürch T, Hollmann R, Wittmann C, Wang W, Deckwer WD (2007)

    Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using 13C labelled substrates.

    Bioproc. Biosyst. Eng. 30:47-59.

  • Fürch T, Wittmann C, Wang W, Franco-Lara E, Jahn D, Deckwer WD (2007)

    The effect of different carbon sources on the central metabolic fluxes and the recombinant protein production in Bacillus megaterium.

    J. Biotechnol. 132:385-394.

  • Fonseca G, Gombert A, Heinzle E, Wittmann C (2007)

    Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source.

    FEMS Yeast Res. 7:422-435.

  • Bolten C J, Kiefer P, Letisse F, Portais J C, Wittmann C (2007)

    Towards appropriate sampling for metabolome analysis of microorganisms.

    Anal. Chem. 79:3843-3849.

  • Becker J, Klopprogge C, Herold A, Zelder O, Bolten C, Wittmann C (2007)

    Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum - over expression and modification of G6P dehydrogenase.

    J. Biotechnol. 132:99-109.