Institut für Systembiotechnologie

Welcome at iSBio

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Gläser L, Kuhl M, Jovanovic S, Fritz M, Vögeli B, Erb T, Becker J, Wittmann C (2020)

    A common approach for absolute quantification of short chain CoA thioesters in prokaryotic and eukaryotic microbes.

    Microb Cell Fact. In press.

  • Becker, J, Wittmann, C (2020)

    Microbial production of extremolytes: high-value active ingredients for nutrition, health care and well-being.

    Curr. Opin. Biotechnol. 65:118-128. PUBMED.

  • Poblete-Castro, I, Hoffmann, SL, Becker, J, Wittmann, C (2020)

    Cascaded valorization of seaweed using microbial cell factories.

    Curr. Opin. Biotechnol. 65:102-113. PUBMED.

iSBio News

iSBio goes on board - BMBF project EXPLOMARE explores novel biotechnological processes based on marine resources

With its new BioProMare initiative, the Federal Ministry of Education and Research (BMBF) is pursuing the goal of recognizing and enabling the biotechnological potential of the marine habitat, which has so far been little explored, but promises new products and services and to support the...


BMBF funds new project for the biotechnological production of nature-derived high-priced protective molecules at the Saar University with 2 million...

In the next three years, the collaborative project EXTRA will focus on the development of novel processes for the fermentative production protective molecules from nature, so-called extremolytes. Extremolytes are small molecules with which microorganisms effectively protect themselves against...


iSBio research featured on the Journal Cover of Biotechnology & Bioengineering

The internationally highly reputed journal "Biotechnology & Bioengineering" features our research on its May 2020 cover page. In the corresponding article that appears in this volume, we have assessed the life cycle of manufacturing adipic acid, one of the global key chemicals, from the...


Alle Artikel in der Übersicht

Hello Wei!

"Hey everyone, my name is Wei Shu and joined the iSBio recently. I completed my MSc in fermentation engineering from East China University of Science and Technology. After graduation, I worked for two years in the fermentation industry..."  [more]

Salut Sabrina!

"My name is Sabrina, I studied biology at the Heinrich-Heine-University in Düsseldorf and did my Bachelor and my Master thesis at the Institute for Microbiology, where I got a very good education in micro- and molecular biology. During this basic research, I realized that I want..."  [more]

This just in!

  Transcriptomics is coming to iSBio

The transcriptome is the complete set of messenger RNA (mRNA) molecules. It displays the set of actively transcribed genes, i.e. the cellular program and actively responds to environmental conditions and genetic modifications. Therefore, transcriptome analysis provides a sensitive readout for fundamental understanding of cellular functions and their optimization... [more]