Institut für Systembiotechnologie

Welcome at the Institute of Systems Biotechnology

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Weiland F, Barton N, Kohlstedt M, Becker J, Wittmann C (2023)

    Systems metabolic engineering upgrades Corynebacterium glutamicum to high-efficiency cis, cis-muconic acid production from lignin-based aromatics.

    Metab. Eng. 75:153-169. PUBMED.

  • Jungmann L, Hoffmann SL, Lang C, De Agazio R, Becker J, Kohlstedt M, Wittmann C (2022)

    High-efficiency production of 5-hydroxyectoine using metabolically engineered Corynebacterium glutamicum.

    Microb. Cell Fact. 21:274. PUBMED.

  • Dolan S, Wijaya A, Kohlstedt M, Gläser L, Brear P, Silva-Rocha R, Wittmann C, Welch M (2022)

    Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism.

    mBio. In press. PUBMEDPreprint.

iSBio News

Novel BMBF-funded project to produce health-promoting omega-3 fatty acids in microbes

Polyunsaturated fatty acids (PUFAs), primarily the marine ones, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have received worldwide attention in recent years due to an increasing awareness of their uniqueness in improving diet and human health and their apparently inevitable...


iSBio to re-program drug producing microbes is featured on the cover of Biotechnology & Bioengineering

The December 2020 back cover highlights a novel strategy that uses microparticles to streamline the lifestyle of the soil microbe Streptomyces towards elevated production of the antituberculosis drug pamamycin, belonging to the polyketide family. As shown in our study, the addition of talc...


You are now a doctor, Sarah!

On December 20, 2020, Sarah Lisa Hoffmann successfully completed her dissertation work, which dealt with a new sustainable production route for the amino acid lysine. Sarah explored a new route for the use of macroalgae, a new type of raw material source from the ocean, which is regarded as third...


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