Institut für Systembiotechnologie

Welcome at iSBio

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Jovanovic S, Dietrich DL, Kohlstedt M, Becker J, Wittmann C (2021)

    Microbial production of polyunsaturated fatty acids – high-value ingredients for aquafeed, superfoods, and pharmaceuticals

    Curr. Opin. Biotechnol. 69:199-211. PUBMED.

  • Borrero-de Acuña JM, Gutierrez-Urrutia I, Hidalgo-Dumont C, Aravena-Carrasco C, Orellana-Saez M, Palominos-Gonzalez N, van Duuren JBJH, Wagner V, Gläser L, Becker J, Kohlstedt M, Zacconi FC, Wittmann C, Poblete-Castro I (2020)

    Channeling carbon flux through the meta-cleavage route for improved poly(3-hydroxyalkanoate) production from benzoate and lignin-based aromatics in Pseudomonas putida H.

    Microb. Biotechnol. In press. PUBMED.

  • Machelart A, Willemart K, Zúñiga-Ripa A, Godard T, Plovier H, Wittmann C, Moriyón I, De Bolle X, Van Schaftingen E, Letesson J, Barbier T (2020)

    Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway.

    PNAS 117:26374-26381. PUBMED.

iSBio News

Novel BMBF-funded project to produce health-promoting omega-3 fatty acids in microbes

Polyunsaturated fatty acids (PUFAs), primarily the marine ones, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have received worldwide attention in recent years due to an increasing awareness of their uniqueness in improving diet and human health and their apparently inevitable...


iSBio to re-program drug producing microbes is featured on the cover of Biotechnology & Bioengineering

The December 2020 back cover highlights a novel strategy that uses microparticles to streamline the lifestyle of the soil microbe Streptomyces towards elevated production of the antituberculosis drug pamamycin, belonging to the polyketide family. As shown in our study, the addition of talc...


You are now a doctor, Sarah!

On December 20, 2020, Sarah Lisa Hoffmann successfully completed her dissertation work, which dealt with a new sustainable production route for the amino acid lysine. Sarah explored a new route for the use of macroalgae, a new type of raw material source from the ocean, which is regarded as third...


Congratulations, Sören!

On the November 6, 2020 Sören Starck successfully completed his dissertation, which dealt with the research of new sustainable production methods based on the waste material lignin. Due to Corona, promotion as a hybrid event was carried out for the first time at the iSBio. In his work,...


Alle Artikel in der Übersicht

Zdravo Berina!

"My name is Berina Muhovic and I come from Sarajevo city, the capital of Bosnia and Herzegovina. Recently, I had the amazing opportunity to join the dynamic lab group and start my Ph.D. at the Institute of Systems Biotechnology (iSBio) at the University of Saarland..."  [mehr]

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