Institut für Systembiotechnologie

Welcome at the Institute of Systems Biotechnology

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Dietrich DL, Jovanovic S, Cao P, Kohlstedt M, Wittmann C (2023)

    Refactoring the genetic architecture of a myxobacterial polyketide gene cluster enables enhanced heterologous docosahexaenoic acid production in Yarrowia lipolytica.

    Microb. Cell Fact. In press

  • Jovanovic S, Dietrich DL, Cao P, Kohlstedt M, Wittmann C (2023)

    Multi-omics view of recombinant Yarrowia lipolytica: Enhanced ketogenic amino acid catabolism increases polyketide-synthase-driven docosahexaenoic production to high selectivity at the gram scale.

    Metab. Eng. 80:45-65. PUBMED.

  • Tangyu M, Fritz M, Tan JP, Ye L, Bolten CJ, Bogicevic B, Wittmann C (2023)

    Flavour by design: Food-grade lactic acid bacteria improve the volatile aroma spectrum of oat milk, sunflower seed milk, pea milk, and faba milk towards improved flavour and sensory perception.

    Microb. Cell Fact. In press.

iSBio News

Saarbrücken biotechnologists conduct research into the production of sustainable recycled...

Nearly 380 million tons of plastics are currently produced each year - with a strong upward trend and the well-known negative consequences for our planet. The EU project "REPurpose" therefore aims...


Novel BMBF-funded project to produce health-promoting omega-3 fatty acids in microbes

Polyunsaturated fatty acids (PUFAs), primarily the marine ones, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have received worldwide attention in recent years due to an increasing...


iSBio to re-program drug producing microbes is featured on the cover of Biotechnology &...

The December 2020 back cover highlights a novel strategy that uses microparticles to streamline the lifestyle of the soil microbe Streptomyces towards elevated production of the antituberculosis...


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