Institut für Systembiotechnologie

Welcome at iSBio

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Borrero-de Acuña JM, Gutierrez-Urrutia I, Hidalgo-Dumont C, Aravena-Carrasco C, Orellana-Saez M, Palominos-Gonzalez N, van Duuren JBJH, Wagner V, Gläser L, Becker J, Kohlstedt M, Zacconi FC, Wittmann C, Poblete-Castro I (2020)

    Channeling carbon flux through the meta-cleavage route for improved poly(3-hydroxyalkanoate) production from benzoate and lignin-based aromatics in Pseudomonas putida H.

    Microb. Biotechnol. In press.

  • Machelart A, Willemart K, Zúñiga-Ripa A, Godard T, Plovier H, Wittmann C, Moriyón I, De Bolle X, Van Schaftingen E, Letesson J, Barbier T (2020)

    Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway.

    PNAS 117:26374-26381. PUBMED.

  • Kuhl M, Gläser L, Rebets Y, Rückert C, Sakhar N, Hartsch T, Kalinowski J, Luzhetskyy A, Wittmann C (2020)

    Microparticles globally reprogram Streptomyces albus towards accelerated morphogenesis, streamlined carbon core metabolism and enhanced production of the antituberculosis polyketide pamamycin.

    Biotechnol. Bioeng. In press. PUBMED.

iSBio News

Implanted microbes as living therapeutics – iSBio-Team programs medical cell factories in the new Leibniz ScienceCampus

The treatment of chronic diseases aims more and more at the of use biological therapeutics, which enable individual and long-term dosage. In this regard, the Leibniz Society now launched the Leibniz Science Campus "Living therapeutic materials" for 4 years. Starting in July 2020, working groups...

mehr

iSBio goes on board - BMBF project EXPLOMARE explores novel biotechnological processes based on marine resources

With its new BioProMare initiative, the Federal Ministry of Education and Research (BMBF) is pursuing the goal of recognizing and enabling the biotechnological potential of the marine habitat, which has so far been little explored, but promises new products and services and to support the...

mehr

BMBF funds new project for the biotechnological production of nature-derived high-priced protective molecules at the Saar University with 2 million...

In the next three years, the collaborative project EXTRA will focus on the development of novel processes for the fermentative production protective molecules from nature, so-called extremolytes. Extremolytes are small molecules with which microorganisms effectively protect themselves against...

mehr

Alle Artikel in der Übersicht

Salut Louis!

"Hello, my name is Louis Burgeat I come from France and I joined the ISBio as a PhD student on September 2020. I did my marine biotechnology master at the European University Institute for Marine Science (IUEM) in Brest, France. I had the opportunity to do my master thesis in Tokyo ..."  [mehr]

Welcome on board, Roxane!

"My name is Roxane Rösner. I did my Bachelor of Biosciences and Master of Biotechnology both at the University of Münster, so I thought it was time for a change of scenery for my PhD position. Saarbrücken and the iSBio seemed a perfect choice to do so! I will join a project team, ..."  [mehr]