Institut für Systembiotechnologie

Welcome at iSBio

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Tangyu, M, Müller J, Bolten, CJ, Wittmann, C (2019)

    Fermentation of plant-based milk alternatives for improved flavour and nutritional value.

    Appl. Microbiol. Biotechnol. in press.

  • Gemperlein, K, Dietrich, D, Kohlstedt, M, Zipf, G, Bernauer, H, Wittmann, C, Wenzel, S, Müller, R (2019)

    Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases

    Nat. Commun. 10:4055. PUBMED.

  • Becker, J, Wittmann, C (2019)

    Pathways at Work – Metabolic Flux Analysis of the Industrial Cell Factory Corynebacterium glutamicum.

    Microbiol. Monogr. In press.

iSBio News

iSBio researchers attend the GIM 2019 conference in Pisa

Five researchers from our iSBio team joined Christoph Wittmann to attend this year’s "International Symposium on the Genetics of Industrial Microbes". The meeting was held from 8th to 11th of July at the conference palace in Pisa, Italy. Over the whole time, GIM 2019 offered an excellent...


Excellent: Best Poster Award for Michael Kohlstedt

Michael Kohlstedt was awarded with the best poster award at the HIPS Symposium, 27-28. July 2019 to highlight his innovative research on the pathogenic bacterium Pseudomonas aeruginosa. Every year in Germany alone, thousands of people die from infections that are caused by this bacterium....


Judith Becker receives the research price of the Hans-and-Ruth Giessen Foundation

Judith Becker from the Institute of System Biotechnology of Saarland University was awarded the price and 20.000 € for her excellent research on tailor-made cell factories. The patronage of the award ceremony on June 13, 2019 in St. Ingbert had taken over Prime Minister Tobias Hans. In her...


Alle Artikel in der Übersicht

Special guest at iSBio

"Hello, I am Dr. Ignacio Poblete-Castro, an Assistant Professor and Group Leader of the Biosystems Engineering Lab at the Center for Bioinformatics and Integrative Biology that belongs to Universidad Andrés Bello, Chile. The main focus of our research group ..."  [more]

Welcome Anna!

"Hello! My name is Anna Weimer. I have a Bachelor's degree in Environmental Management from Justus Liebig University in Giessen and a Master's degree in Biotechnology from the University of Lund in Sweden. The topic of sustainability is very important to me and has accompanied me since my early childhood ..."  [more]

This just in!

  Transcriptomics is coming to iSBio

The transcriptome is the complete set of messenger RNA (mRNA) molecules. It displays the set of actively transcribed genes, i.e. the cellular program and actively responds to environmental conditions and genetic modifications. Therefore, transcriptome analysis provides a sensitive readout for fundamental understanding of cellular functions and their optimization... [more]