Institut für Systembiotechnologie

Research areas

The Institute of Systems Biotechnology (Saarland University) is dedicated to explore and design microbial metabolism on a quantitative systems level. In national and international collaborations our team of biologists, bioengineers, molecular and computer scientists approaches fundamental and applied research questions on the design of tailor-made cell factories, the development of sustainable bioprocesses from renewables and the metabolism of infectious bacteria. Our research focusses on three key areas:


Systems Metabolic Engineering for Industrial Bioproduction

We have a long-lasting expertise to use natural raw materials for the production of food ingredients and green chemicals. Today, we design and create cell factories for bio-production using systems metabolic engineering. Integrating systems biology and biotechnology with new concepts from synthetic biology, systems metabolic engineering enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility, otherwise not accessible. more


Industrial Systems Biology - Understanding Biological Systems

We use experimental and computational approaches to understand biological systems in a holistic way. In different projects, we investigate bacteria, yeasts, fungi and even whole plants on the systems level using our technology platforms. The technological specialty of our group is 13C metabolic flux analysis, computer-based simulations of metabolic pathway and pathway networks. more


Pharmaceutical and Medical Systems Biology

Microbial pathogens are a threat for human health and we face increasing therapeutic problems due to the emergence of multidrug resistant strains. Obviously, these bacteria have evolved a complex, fine-tuned machinery to resist against host defense mechanisms and therapeutic treatments. Here, we take a systems view to understand the life style and the resistance mediating mechanisms of pathogenic bacteria. more

iSBio News

Christoph Wittmann delivers keynote lecture at MES 2019 in Tianjin

The international ME conference is the world leading conference in the field of metabolic engineering. It brings together leading experts, scientists, and students from industry, the government and...


iSBio researchers attend the GIM 2019 conference in Pisa

Five researchers from our iSBio team joined Christoph Wittmann to attend this year’s "International Symposium on the Genetics of Industrial Microbes". The meeting was held from 8th to 11th of...


Excellent: Best Poster Award for Michael Kohlstedt

Michael Kohlstedt was awarded with the best poster award at the HIPS Symposium, 27-28. July 2019 to highlight his innovative research on the pathogenic bacterium Pseudomonas aeruginosa. Every year in...


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