Institut für Systembiotechnologie

Research areas

The Institute of Systems Biotechnology (Saarland University) is dedicated to explore and design microbial metabolism on a quantitative systems level. In national and international collaborations our team of biologists, bioengineers, molecular and computer scientists approaches fundamental and applied research questions on the design of tailor-made cell factories, the development of sustainable bioprocesses from renewables and the metabolism of infectious bacteria. Our research focusses on three key areas:


Systems Metabolic Engineering for Industrial Bioproduction

We have a long-lasting expertise to use natural raw materials for the production of food ingredients and green chemicals. Today, we design and create cell factories for bio-production using systems metabolic engineering. Integrating systems biology and biotechnology with new concepts from synthetic biology, systems metabolic engineering enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility, otherwise not accessible. more


Industrial Systems Biology - Understanding Biological Systems

We use experimental and computational approaches to understand biological systems in a holistic way. In different projects, we investigate bacteria, yeasts, fungi and even whole plants on the systems level using our technology platforms. The technological specialty of our group is 13C metabolic flux analysis, computer-based simulations of metabolic pathway and pathway networks. more


Pharmaceutical and Medical Systems Biology

Microbial pathogens are a threat for human health and we face increasing therapeutic problems due to the emergence of multidrug resistant strains. Obviously, these bacteria have evolved a complex, fine-tuned machinery to resist against host defense mechanisms and therapeutic treatments. Here, we take a systems view to understand the life style and the resistance mediating mechanisms of pathogenic bacteria. more

iSBio News

Implanted microbes as living therapeutics – iSBio-Team programs medical cell factories in...

The treatment of chronic diseases aims more and more at the of use biological therapeutics, which enable individual and long-term dosage. In this regard, the Leibniz Society now launched the Leibniz...


iSBio goes on board - BMBF project EXPLOMARE explores novel biotechnological processes based on...

With its new BioProMare initiative, the Federal Ministry of Education and Research (BMBF) is pursuing the goal of recognizing and enabling the biotechnological potential of the marine habitat, which...


BMBF funds new project for the biotechnological production of nature-derived high-priced...

In the next three years, the collaborative project EXTRA will focus on the development of novel processes for the fermentative production protective molecules from nature, so-called...


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